Degree Type

Dissertation

Date of Award

2008

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

Robert S. Houk

Second Advisor

Jacob W. Petrich

Third Advisor

Emily A. Smith

Abstract

Particle size effects and elemental fractionation in laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) are investigated with nanosecond and femtosecond laser ablation, differential mobility analysis, and magnetic sector ICP-MS. Laser pulse width was found to have a significant influence on the LA particle size distribution and the elemental composition of the aerosol and thus fractionation. Emission from individual particles from solution nebulization, glass, and a pressed powder pellet are observed with high speed digital photography. The presence of intact particles in an ICP is shown to be a likely source of fractionation. A technique for the online detection of stimulated elemental release from neural tissue using magnetic sector ICP-MS is described. Detection limits of 1 mug L-1 or better were found for P, Mn, Fe, Cu, and Zn in a 60 muL injection in a physiological saline matrix.

DOI

https://doi.org/10.31274/rtd-180813-16946

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Nathan Joe Saetveit

Language

en

Proquest ID

AAI3330733

OCLC Number

316221332

ISBN

9780549864790

File Format

application/pdf

File Size

93 pages

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