Degree Type

Dissertation

Date of Award

2008

Degree Name

Doctor of Philosophy

Department

Theses & dissertations (Interdisciplinary)

Major

Bioinformatics and Computational Biology

First Advisor

Dianne Cook

Second Advisor

Eve Wurtele

Third Advisor

Heike Hofmann

Abstract

Biologists need to analyze and comprehend increasingly large and more complex multivariate experimental data. Biological experiments often produce multiple data sets, each describing one aspect of the system, such as the transcriptome recorded by a microarray or metabolome recorded using gas chromatography mass spectrometry (GC-MS). A biochemical network model provides a conceptual system-level framework for integrating data from different sources.;Effective use of graphics enhances the comprehension of data, and interactive graphics permit the analyst to actively explore data, check its integrity, satiate curiosities and reveal the unexpected. Interactive graphics have not been widely applied as a means for understanding data from biological experiments.;This thesis addresses these needs by providing new methods and software that apply interactive graphics in coordination with numerical methods to the analysis of biological data, in a manner that is accessible to biologists.

DOI

https://doi.org/10.31274/rtd-180813-17081

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Michael Lawrence

Language

en

Proquest ID

AAI3307049

OCLC Number

243639967

ISBN

9780549542940

File Format

application/pdf

File Size

306 pages

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