Date of Award
Doctor of Philosophy
Chemical and Biological Engineering
Surya K. Mallapragada
Water-soluble stimuli responsive block copolymers are a rapidly emerging class of materials with great potential in biomedical and technological applications. In this work a novel class of pentablock copolymers are synthesized via atom transfer radical polymerization techniques and their stimuli-responsive self-assembly properties are characterized. Aqueous solutions of these materials are observed to form micelles and hydrogels in response to changes in both temperature and pH. Cryogenic transmission electron microscopy (cryo-TEM) and small angle neutron and X-ray scattering (SANS and SAXS) techniques are used to investigate the nanoscale structures formed by these pentablock copolymers in solution. The gel structure and mechanical properties are investigated with SANS and rheological techniques. The multi-responsive properties of these materials are utilized to formulate a stimuli responsive drug delivery formulation that exhibits thermoreversible gelation and pH dependent release rate of model drugs.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Michael Duane Determan
Determan, Michael Duane, "Synthesis and characterization of stimuli responsive block copolymers, self-assembly behavior and applications " (2006). Retrospective Theses and Dissertations. 1810.