Degree Type

Dissertation

Date of Award

2006

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

First Advisor

Peter J. Reilly

Second Advisor

Zhijun Wu

Abstract

Carbohydrates are important molecules in energy storage and cellular recognition. New methods are used and discussed to capture important structural details of created by the protein/carbohydrate interactions. In particular, the thermodynamics of carbohydrate binding are explored, and a new model to accurately calculate the free energy of binding is developed. Additionally, a new method of describing the pucker of carbohydrate ring with three coordinates is discussed. These methods are then applied to Family 1 Glycoside Hydrolases.

DOI

https://doi.org/10.31274/rtd-180813-16458

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Anthony David Hill

Language

en

Proquest ID

AAI3243823

File Format

application/pdf

File Size

176 pages

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