This thesis examines the topic of imagination and creativity in design. I examine the methods and motivations of artists and designers who have succeeded in creating works that are both unusual and thought provoking. By incorporating the careful analysis of neurological disorders into a design method transferred from a design method used by some artists, I am able to develop 'design tactics' that aid and inform architectural design. The end result is the 'Vessel of Folly'; a ship composed of various parts created using design tactics developed from different case studies of people with neurological disorders.