Degree Type

Dissertation

Date of Award

1981

Degree Name

Doctor of Philosophy

Department

Veterinary Physiology and Pharmacology

Abstract

An intravaginal device (U.S. Patent application no. 124,542) was developed for Canis familiaris to deliver a contraceptive drug. Fifteen females were treated with mibolerone and 5 females were given placebos. The delivery device was placed intravaginally approximately one month before the expected estrus. Each delivery device remained intravaginally for a three month period and then was removed;The criteria for the suppression of estrus were based upon plasma progesterone levels, vaginal smears, physical examinations and observations. The vaginal smears were collected weekly and gross physical examinations and observations were made daily. Blood samples were collected once every two weeks during the test period. The plasma samples then were radioimmunoassayed for progesterone;From this study, the following conclusions can be drawn: (1) Mibolerone delivered intravaginally did inhibit estrus in beagles. (2) The slow releasing delivery device was successful in delivering mibolerone and it was compatible with placement in the vaginal canal. (3) It is believed that the delivery device could provide an economical, non-surgical, reversible means of preventing estrus in the female canine.

DOI

https://doi.org/10.31274/rtd-180813-11212

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Keith Edward Magoon

Language

en

Proquest ID

AAI8122538

File Format

application/pdf

File Size

106 pages

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