Date of Award
Doctor of Philosophy
Veterinary Physiology and Pharmacology
An intravaginal device (U.S. Patent application no. 124,542) was developed for Canis familiaris to deliver a contraceptive drug. Fifteen females were treated with mibolerone and 5 females were given placebos. The delivery device was placed intravaginally approximately one month before the expected estrus. Each delivery device remained intravaginally for a three month period and then was removed;The criteria for the suppression of estrus were based upon plasma progesterone levels, vaginal smears, physical examinations and observations. The vaginal smears were collected weekly and gross physical examinations and observations were made daily. Blood samples were collected once every two weeks during the test period. The plasma samples then were radioimmunoassayed for progesterone;From this study, the following conclusions can be drawn: (1) Mibolerone delivered intravaginally did inhibit estrus in beagles. (2) The slow releasing delivery device was successful in delivering mibolerone and it was compatible with placement in the vaginal canal. (3) It is believed that the delivery device could provide an economical, non-surgical, reversible means of preventing estrus in the female canine.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Keith Edward Magoon
Magoon, Keith Edward, "Canine estrus suppression with mibolerone delivered by an intravaginal device " (1981). Retrospective Theses and Dissertations. 6829.