Date of Award
Doctor of Philosophy
Chemical and Biological Engineering
High level, long term release of oxytetracycline HCl into artificial rumens was accomplished by a controlled release device. Three controlled release devices delivered 16.33, 8.15, and 9.31 mg/day for 52, 63, and 63 days, respectively. Theory for the controlled release devices predicted release rates of 13.30, 13.48, and 13.63 mg/day for 59.19, 58.34, and 58.63 days, respectively. The release rates were nearly zero-order. The discrepancies between the experimentally determined release kinetics and those predicted by theory were largely attributed to environmental factors;The artificial rumens were found to be viable representations of in vivo rumens up to 92 days based upon pH measurements and volatile fatty acid production. No significant shifts in volatile fatty acid production were noted for the artificial rumens influenced by oxytetracycline HCl release from the delivery devices;Utilization of this controlled release system to administer oxytetracycline HCl and possibly other beneficial agents to ruminants appears to be feasible.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Thomas Harry Ferguson
Ferguson, Thomas Harry, "High level, long term delivery of oxytetracycline HC1 from a controlled release device in an artificial rumen " (1981). Retrospective Theses and Dissertations. 7165.