Degree Type

Dissertation

Date of Award

1981

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

Abstract

High level, long term release of oxytetracycline HCl into artificial rumens was accomplished by a controlled release device. Three controlled release devices delivered 16.33, 8.15, and 9.31 mg/day for 52, 63, and 63 days, respectively. Theory for the controlled release devices predicted release rates of 13.30, 13.48, and 13.63 mg/day for 59.19, 58.34, and 58.63 days, respectively. The release rates were nearly zero-order. The discrepancies between the experimentally determined release kinetics and those predicted by theory were largely attributed to environmental factors;The artificial rumens were found to be viable representations of in vivo rumens up to 92 days based upon pH measurements and volatile fatty acid production. No significant shifts in volatile fatty acid production were noted for the artificial rumens influenced by oxytetracycline HCl release from the delivery devices;Utilization of this controlled release system to administer oxytetracycline HCl and possibly other beneficial agents to ruminants appears to be feasible.

DOI

https://doi.org/10.31274/rtd-180813-5131

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Thomas Harry Ferguson

Language

en

Proquest ID

AAI8122512

File Format

application/pdf

File Size

136 pages

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