Degree Type

Dissertation

Date of Award

1983

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

Abstract

A hypothesis that altering extracellular concentrations of calcium and magnesium (Ca('++)e, Mg('++)e) would produce quantitatively different effects on the neurally evoked isometric responses of slow muscles, as represented by soleus (SOL), and fast muscles, as represented by extensor digitorum longus (EDL) of the rat, was tested;Isometric twitch and tetanic tensions, in response to nerve and muscle stimulation, were recorded in situ from animals with intact vascular systems and animals which had one hind limb perfused with a normal Krebs solution or an altered Krebs solution. Four combinations of altered Ca('++)e and Mg('++)e were perfused to determine whether transmission would be affected more at one type of neuromuscular junction than at the other;In response to decreased Ca('++)e alone and decreased Ca('++)e and increased Mg('++)e, single twitch tension decreased less in the EDL than in the SOL neuromuscular system; tetanic tension decreased more in the EDL than in the SOL.

DOI

https://doi.org/10.31274/rtd-180813-5983

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Komli-Kofi Atsina

Language

en

Proquest ID

AAI8323264

File Format

application/pdf

File Size

99 pages

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