Date of Award
Doctor of Philosophy
Chemical and Biological Engineering
A hypothesis that altering extracellular concentrations of calcium and magnesium (Ca('++)e, Mg('++)e) would produce quantitatively different effects on the neurally evoked isometric responses of slow muscles, as represented by soleus (SOL), and fast muscles, as represented by extensor digitorum longus (EDL) of the rat, was tested;Isometric twitch and tetanic tensions, in response to nerve and muscle stimulation, were recorded in situ from animals with intact vascular systems and animals which had one hind limb perfused with a normal Krebs solution or an altered Krebs solution. Four combinations of altered Ca('++)e and Mg('++)e were perfused to determine whether transmission would be affected more at one type of neuromuscular junction than at the other;In response to decreased Ca('++)e alone and decreased Ca('++)e and increased Mg('++)e, single twitch tension decreased less in the EDL than in the SOL neuromuscular system; tetanic tension decreased more in the EDL than in the SOL.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Atsina, Komli-Kofi, "Isometric responses of rat extensor digitorum longus and soleus neuromuscular systems to abnormal extracellular calcium and magnesium concentrations " (1983). Retrospective Theses and Dissertations. 7695.