Degree Type
Dissertation
Date of Award
1983
Degree Name
Doctor of Philosophy
Department
Chemical and Biological Engineering
Abstract
A hypothesis that altering extracellular concentrations of calcium and magnesium (Ca('++)e, Mg('++)e) would produce quantitatively different effects on the neurally evoked isometric responses of slow muscles, as represented by soleus (SOL), and fast muscles, as represented by extensor digitorum longus (EDL) of the rat, was tested;Isometric twitch and tetanic tensions, in response to nerve and muscle stimulation, were recorded in situ from animals with intact vascular systems and animals which had one hind limb perfused with a normal Krebs solution or an altered Krebs solution. Four combinations of altered Ca('++)e and Mg('++)e were perfused to determine whether transmission would be affected more at one type of neuromuscular junction than at the other;In response to decreased Ca('++)e alone and decreased Ca('++)e and increased Mg('++)e, single twitch tension decreased less in the EDL than in the SOL neuromuscular system; tetanic tension decreased more in the EDL than in the SOL.
DOI
https://doi.org/10.31274/rtd-180813-5983
Publisher
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Copyright Owner
Komli-Kofi Atsina
Copyright Date
1983
Language
en
Proquest ID
AAI8323264
File Format
application/pdf
File Size
99 pages
Recommended Citation
Atsina, Komli-Kofi, "Isometric responses of rat extensor digitorum longus and soleus neuromuscular systems to abnormal extracellular calcium and magnesium concentrations " (1983). Retrospective Theses and Dissertations. 7695.
https://lib.dr.iastate.edu/rtd/7695
