Date of Award
Doctor of Philosophy
Veterinary Physiology and Pharmacology
Parturient paresis (milk fever) is a hypocalcemic disorder of dairy cows associated with the onset of lactation. In these studies, we have evaluated the ability of two calcitropic hormones, 1,25-dihydroxyvitamin D and parathyroid hormone, to prevent parturient paresis;Studies utilizing 1,25-dihydroxyvitamin D and its fluorinated analogues established that these compounds will prevent hypocalcemia if administered at the proper time prior to parturition. These studies confirm earlier work that the vitamin D compounds are effective solely by virtue of their ability to increase intestinal absorption of calcium. The studies also warn of possible renal toxicity that may accompany use of these compounds at high doses;Parathyroid hormone was found to increase plasma calcium concentration in periparturient cows through its activity on bone calcium resorption mechanisms, renal calcium conservation, and intestinal calcium absorption via its stimulation of the production of 1,25-dihydroxyvitamin D. These studies establish that parathyroid hormone can prevent parturient paresis in dairy cattle.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Jesse Paul Goff
Goff, Jesse Paul, "Prevention of parturient paresis (milk fever) in dairy cows " (1986). Retrospective Theses and Dissertations. 8001.