Degree Type

Dissertation

Date of Award

1986

Degree Name

Doctor of Philosophy

Department

Veterinary Physiology and Pharmacology

Abstract

Parturient paresis (milk fever) is a hypocalcemic disorder of dairy cows associated with the onset of lactation. In these studies, we have evaluated the ability of two calcitropic hormones, 1,25-dihydroxyvitamin D and parathyroid hormone, to prevent parturient paresis;Studies utilizing 1,25-dihydroxyvitamin D and its fluorinated analogues established that these compounds will prevent hypocalcemia if administered at the proper time prior to parturition. These studies confirm earlier work that the vitamin D compounds are effective solely by virtue of their ability to increase intestinal absorption of calcium. The studies also warn of possible renal toxicity that may accompany use of these compounds at high doses;Parathyroid hormone was found to increase plasma calcium concentration in periparturient cows through its activity on bone calcium resorption mechanisms, renal calcium conservation, and intestinal calcium absorption via its stimulation of the production of 1,25-dihydroxyvitamin D. These studies establish that parathyroid hormone can prevent parturient paresis in dairy cattle.

DOI

https://doi.org/10.31274/rtd-180813-5727

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Jesse Paul Goff

Language

en

Proquest ID

AAI8615048

File Format

application/pdf

File Size

140 pages

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