Date of Award
Doctor of Philosophy
Chemical and Biological Engineering
The integrity of the anterior tibialis muscle in the rodent was investigated for conditions of normal and complete occlusion of nutrient iliac blood flow. Integrity was defined as the ability of the muscle to contract during severe ischemia. Occlusion of the iliac vessel was accomplished by mechanical ligation or thromboplastin-induced arterial thrombosis;This research examined the alteration of peripheral hemodynamics with acute vascular insufficiency in the left hind limb of the exercised and sedentary rat. The techniques presented suggest that characterization of the rodent hind limb vascular supply was possible by both hemodynamic evaluation and electromyographic analysis. The importance of vascular supply on muscle performance was demonstrated. This was correlated not only to the reactive hyperemic state of the limb but also to dynamic work capacity of the anterior tibialis muscle under induced loading as measured by the electromyogram.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Mark Irwin Darrah
Darrah, Mark Irwin, "Physiological effects of blood flow through a region of induced atherosclerosis in the rat with emphasis on the effect of exercise on thrombosis and collateral vessel recruitment " (1982). Retrospective Theses and Dissertations. 8340.