Degree Type

Dissertation

Date of Award

1984

Degree Name

Doctor of Philosophy

Department

Chemical and Biological Engineering

Abstract

Sixteen mongrel dogs were tested for hepatic removal of indocyanine green (ICG) dye in normal animals and animals with portal-caval shunts. Characteristics of blood ICG clearance and bile ICG accumulation were studied. Response of the mathematical model is similar to the response from the studies of normal animals when programmed with initial parameters taken from the animal studies. A data-handling system was developed for the acquisition of the experimental data. Cardiac output decreased two-fold (p < 0.01) following a portal-caval shunt. Dye decay rate in the plasma decreased (p < 0.05) which resulted in an increase in area under the blood concentration curve and time to zero concentration in the shunted animals. Mean bile flow was reduced two-fold (p < 0.05) while the area under the ascending bile curve increased (p < 0.05) in the shunted animals. A method in which to measure the volume of the bile canalicular space has been discovered by analysis of the descending portion of the bile dye curve. Effects of methoxyfluorane-nitrous oxide anesthetic on the hepatic system appear to be minimal with respect to dye clearance as seen by relatively small differences between the animal data and the mathematical model.

DOI

https://doi.org/10.31274/rtd-180813-8937

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Paul Joseph Antol

Language

en

Proquest ID

AAI8423619

File Format

application/pdf

File Size

133 pages

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