Degree Type

Dissertation

Date of Award

1990

Degree Name

Doctor of Philosophy

Department

Genetics

First Advisor

Jack R. Girton

Abstract

The Notch gene is a member of one of the sets of genes that control the developmental pathways that specify cell fate decisions in Drosophila melanogaster. The goal of this research was to use a genetic approach to identify and characterize a gene that functions with Notch in a cell fate pathway. A candidate was found in a new mutation that causes phenotypes similar to Notch and that interacts phenotypically with Notch mutations. This mutation was identified as a mutation of the deltex gene. The deltex gene was mapped to the salivary chromosome band region 6AB. Mutant phenotypes in the wings, legs, eyes, ocelli, and bristles were demonstrated. The mutant phenotypes of deltex are consistent with the hypothesis that deltex functions in a cell fate pathway. A comparison of deltex mutant phenotypes with Notch mutant phenotypes showed that the phenotypes are very similar. Synergistic phenotypic interactions between mutations of deltex and mutations of Notch showed that deltex and Notch function together in the wings, legs, eyes, ocelli, and bristles. The results of these investigations lead to the conclusion that the deltex gene functions with the Notch gene in one or more developmental pathways to specify individual cell fate.

DOI

https://doi.org/10.31274/rtd-180813-9206

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Maureen Joan Gorman

Language

en

Proquest ID

AAI9110502

File Format

application/pdf

File Size

117 pages

Included in

Genetics Commons

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