Degree Type

Dissertation

Date of Award

1991

Degree Name

Doctor of Philosophy

Department

Theses & dissertations (Interdisciplinary)

Major

Immunobiology

First Advisor

Susan J. Lamont

Abstract

The S1 line of chickens contains four sublines based on Ea-B type (B[superscript]1 or B[superscript]19) and high or low antibody response to GAT (Ir-GAT), a linear amino acid polymer of glutamic acid[superscript]60-alanine[superscript]30-tyrosine[superscript]10. There is evidence of recombination between the serologically determined regions of the MHC (encoded by B-F and B-G genes) and the gene(s) that control immune response to GAT. The appendix of this dissertation provides evidence that immune response to GAT serves as a genetic marker for Marek's disease resistance;Alloantisera produced by immunizations between Ir-GAT[superscript] Low and Ir-GAT[superscript] High chickens and stringently tested, never supported the hypothesis that response to GAT was mediated by B-L gene products. Measurements of proliferation of GAT-primed T lymphocytes indicated that reactivity in vitro was not associated with the antibody levels produced in the animal;The ability of antigen-presenting cells (APC) to process and present GAT to responder T cells was tested in vitro. Results indicated that the Ir-GAT[superscript] Low APC from Ea-B[superscript]1 birds produced higher (P 0.001) associated with the B blood type of these progeny.

DOI

https://doi.org/10.31274/rtd-180813-17442

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Edward Merrill Steadham

Language

en

Proquest ID

AAI9212194

File Format

application/pdf

File Size

127 pages

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