Date of Award
Doctor of Philosophy
Theses & dissertations (Interdisciplinary)
Susan J. Lamont
The S1 line of chickens contains four sublines based on Ea-B type (B[superscript]1 or B[superscript]19) and high or low antibody response to GAT (Ir-GAT), a linear amino acid polymer of glutamic acid[superscript]60-alanine[superscript]30-tyrosine[superscript]10. There is evidence of recombination between the serologically determined regions of the MHC (encoded by B-F and B-G genes) and the gene(s) that control immune response to GAT. The appendix of this dissertation provides evidence that immune response to GAT serves as a genetic marker for Marek's disease resistance;Alloantisera produced by immunizations between Ir-GAT[superscript] Low and Ir-GAT[superscript] High chickens and stringently tested, never supported the hypothesis that response to GAT was mediated by B-L gene products. Measurements of proliferation of GAT-primed T lymphocytes indicated that reactivity in vitro was not associated with the antibody levels produced in the animal;The ability of antigen-presenting cells (APC) to process and present GAT to responder T cells was tested in vitro. Results indicated that the Ir-GAT[superscript] Low APC from Ea-B[superscript]1 birds produced higher (P 0.001) associated with the B blood type of these progeny.
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Edward Merrill Steadham
Steadham, Edward Merrill, "T lymphocyte reactivity and antibody response to a synthetic peptide (glutamic acid-alanine-tyrosine) as a marker for disease resistance in chickens " (1991). Retrospective Theses and Dissertations. 9778.