Degree Type

Dissertation

Date of Award

1992

Degree Name

Doctor of Philosophy

Department

Chemistry

Abstract

The synthesis of analogs of biologically important compounds has been a very exciting area of organic chemistry. As a consequence of their interesting activities, many synthetic approaches have been developed. Our synthetic approaches toward analogs of glutamic acid, tetracycline, and mitomycin represent a valuable contribution to organic and biological chemistry;The reaction of cyclopropane bromodiester with base in liquid ammonia gave the aminocyclopropane diesters which could be converted to the diacids, analogs of glutamic acid;The tetracyclines have an antibiotic activity and a novel metal ion chelating ability. Several possible chelating analogs of tetracycline have been prepared;The intramolecular cyclization of N-acylated indoles gave cyclized products which have the ring system in the mitomycins. This cyclization can be effected by either radical or organopalladium mediated reactions.

DOI

https://doi.org/10.31274/rtd-180813-9364

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Hak Won Kim

Language

en

Proquest ID

AAI9220973

File Format

application/pdf

File Size

103 pages

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