Degree Type

Dissertation

Date of Award

2002

Degree Name

Doctor of Philosophy

Department

Kinesiology

First Advisor

Douglas S. King

Abstract

Ingesting androstenedione alone or with herbal extracts, or androstenediol with herbal extracts purportedly increases serum [testosterone] in men. The addition of herbal extracts is purported to prevent the conversion of testosterone precursors into estrogens or dihydrotestosterone. The effects of ingesting androstenedione, androstenedione + herbal extracts, and androstenediol + herbal extracts on serum [testosterone], [estradiol], [dihydrotestosterone], [prostate specific antigen] (PSA), and blood lipids was investigated in 30 to 59 year old men. Subjects were randomly assigned to consume ASD (300 mg/day androstenedione; n = 28), DION (300-mg androstenedione, 150-mg dehydroepiandrosterone, 540-mg saw palmetto, 300-mg indole-3-carbinol, 625-mg chrysin, and 750-mg Tribulus terrestris per day; n = 28), AND-HB (300-mg androstenediol, 480-mg saw palmetto, 450-mg indole-3-carbinol, 300-mg chrysin, 1,500 mg gamma-linolenic acid, and 1,350-mg Tribulus terrestris per day; n = 28), or placebo (n = 27) for 28 days. Serum [free testosterone], [total testosterone], [androstenedione], [dihydrotestosterone], [estradiol], [PSA], and [lipids] were measured before and throughout the 4-week supplementation period. Serum [total testosterone] and [PSA] were unchanged by supplementation. Serum [androstenedione] (174%, 342%, and 300%), [free testosterone] (37%, 38%, and 45%), [dihydrotestosterone] (57%, 71%, and 83%), and [estradiol] (86%, 103%, 68%) were elevated (P < 0.05) for AND-HB, DION, and ASD, respectively. Serum [HDL-C] was reduced (P < 0.05) similarly by 0.13 mmol·l-1 in ASD, DION and AND-HB. There is no difference in the serum [testosterone], [estradiol], [dihydrotestosterone], [PSA], and [lipid] response to ingesting androstenedione alone, androstenedione + herbal extracts, or androstenediol + herbal extracts.;Orally ingested androgens undergo a large degree of digestive and hepatic breakdown. Therefore, we evaluated the hormonal response to sublingual cyclodextrin androstenediol. Eight males (22.9 +/- 1.2 y) consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (SL-DIOL) or placebo. Blood samples were collected before supplementation and every 30-min for 3 h after supplementation. Serum [androstenedione] was increased 125% at 120 min, serum [free testosterone] was increased 118% at 60 min, serum [total testosterone] was increased 110% at 60 min, and serum [estradiol] was 71% elevated at 180 min in SL-DIOL. These data indicate that, in contrast to ingested androstenediol, sublingual cyclodextrin androstenediol intake increases serum [androstenedione], [free testosterone], [total testosterone], and [estradiol].

DOI

https://doi.org/10.31274/rtd-180813-8799

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu

Copyright Owner

Gregory Allen Brown

Language

en

Proquest ID

AAI3061816

File Format

application/pdf

File Size

145 pages

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