Degree Type
Dissertation
Date of Award
1992
Degree Name
Doctor of Philosophy
Department
Chemistry
First Advisor
George A. Kraus
Abstract
Organic synthesis is as highly developed, versatile, and interdisciplinary branch of natural science. Modern synthetic methods have been developed to allow us the preparation of complex molecules and new materials with unique properties. The accomplishments discussed in this thesis including the following: (1) The convergent and stereoselective total synthesis of paulownin using the type II photocyclization reaction. (2) The efficient synthesis of aklavinone antibiotic utilizing a photoenolization/Diels-Alder reaction and palladium-catalyzed aromatization sequence. (3) A direct synthetic approach to the pleurotin anticancer agent featuring the photoenolization and highly stereoselective intramolecular Diels-Alder reactions, and the finding of the new lead in the discovery of therapeutic anticancer agents.
DOI
https://doi.org/10.31274/rtd-180813-9467
Publisher
Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/
Copyright Owner
Li Chen
Copyright Date
1992
Language
en
Proquest ID
AAI9234795
File Format
application/pdf
File Size
112 pages
Recommended Citation
Chen, Li, "Photoinduced hydrogen atom abstraction in natural products synthesis " (1992). Retrospective Theses and Dissertations. 9980.
https://lib.dr.iastate.edu/rtd/9980
