Degree Type

Dissertation

Date of Award

1992

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

George A. Kraus

Abstract

Organic synthesis is as highly developed, versatile, and interdisciplinary branch of natural science. Modern synthetic methods have been developed to allow us the preparation of complex molecules and new materials with unique properties. The accomplishments discussed in this thesis including the following: (1) The convergent and stereoselective total synthesis of paulownin using the type II photocyclization reaction. (2) The efficient synthesis of aklavinone antibiotic utilizing a photoenolization/Diels-Alder reaction and palladium-catalyzed aromatization sequence. (3) A direct synthetic approach to the pleurotin anticancer agent featuring the photoenolization and highly stereoselective intramolecular Diels-Alder reactions, and the finding of the new lead in the discovery of therapeutic anticancer agents.

DOI

https://doi.org/10.31274/rtd-180813-9467

Publisher

Digital Repository @ Iowa State University, http://lib.dr.iastate.edu/

Copyright Owner

Li Chen

Language

en

Proquest ID

AAI9234795

File Format

application/pdf

File Size

112 pages

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