In 1996 the Food and Drug Administration Center for Veterinary Medicine established the National Ant1microbial Resistance Monitoring System - Enteric Bacteria (NARMS) as a post-approval monitoring program. From 1997 through 2005, 10,565 Salmonella isolates originated from swine slaughter/processing (n=3,848), diagnostic (n=4,579) and on-farm (n=2138) sources as part of the animal arm of NARMS. Relative to 2005, the top five Salmonella serotypes from slaughter/processing (in decreas1ng frequency) were S. Derby, S. Typhimunum var. 5-, S lnfantis, S Anatum, and S Johannesburg while diagnostic serotypes were S Typhimurium var 5-, S Choleraesuis var kunzendorf, S Derby, S Typhimunum, and S Heidelberg Increased antimicrobial restistance was most often observed for diagnostic versus slaughter/processing isolates although there were exceptions for some drug and serotype combinations. For all years, greater than 55% of the slaughter/processing isolates were either pan-susceptible or resistant to only one antimicrobial, which was most often tetracycline. Since 1997, approximately 41% of the isolates exhibited multi-drug resistance, defined as resistance to ~2 antimicrobials. Of the 723 S Typhimunum DT104 isolates from swme only 24% (n=176) originated from slaughter/processmg These data reaffirm that overall patterns of resistance are highly dependent on the Salmonella serotype distribution and is variable when measured at different points along the farm to fork continuum.