Porcine Enteropathy also known as ileitis in pigs, caused by Lawsonia intracellularis, is regarded as one of the major gut related health issues in pork production. Recent reports from national institutes for pharmaceutical products show that the annual amount of antibiotics against enteric diseases has increased over the last few years. Despite the ban of antimicrobial growth promoters in Europe since January 2006, the total amount of antibiotics used in pigs does not seem to be significantly reduced. This is contradictory to the demands of the consumers for a reduction in antibiotic use and the efforts to reduce the risk of antibiotic resistance. Recently several field studies have demonstrated that the use of Enterisol ileitis (Boehringer lngelheim), a vaccine against ileitis can reduce the amount of antibiotics needed to prevent this disease. Additionally, vaccination can contribute to the overall reduction in use of antimicrobials on farms due to the higher health status of the farms. This oral vaccine is therefore a better alternative compared to antibiotics to prevent ileitis.