Publication Date

January 2011

Abstract

Swine are often asymptomatic carriers of Salmonella spp. Interventions are needed to limit Salmonella colonization of swine to enhance food safety. An attenuated Salmonella enterica serovar Typhimurium mutant strain (BBS 202) was tested in swine to determine whether vaccination could provide protection against wild-type S. Typhimurium challenge. Two groups of piglets (n=14/group) received an intranasal inoculation of BBS 202 or a PBS placebo at 6-weeks of age with a booster 2-weeks later. At 11-weeks of age, all pigs were challenged with the parental, wild-type S. Typhimurium by intranasal inoculation.

Book Title

77th International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork

Pages

228-231

Language

en

File Format

application/pdf

DOI

https://doi.org/10.31274/safepork-180809-629

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Jan 1st, 12:00 AM

Serological Response of Swine to an Attenuated Salmonella enterica serovar Typhimurium Strain that Reduces Gastrointestinal Colonization, Fecal Shedding and Disease due to Virulent Salmonella Typhimurium

Maastricht, Netherlands

Swine are often asymptomatic carriers of Salmonella spp. Interventions are needed to limit Salmonella colonization of swine to enhance food safety. An attenuated Salmonella enterica serovar Typhimurium mutant strain (BBS 202) was tested in swine to determine whether vaccination could provide protection against wild-type S. Typhimurium challenge. Two groups of piglets (n=14/group) received an intranasal inoculation of BBS 202 or a PBS placebo at 6-weeks of age with a booster 2-weeks later. At 11-weeks of age, all pigs were challenged with the parental, wild-type S. Typhimurium by intranasal inoculation.