Campus Units
Animal Science, Statistics
Document Type
Conference Proceeding
Conference
15th Annual Conference on Applied Statistics in Agriculture
Publication Version
Published Version
Publication Date
2003
Journal or Book Title
Proceedings of the 15th Annual Conference on Applied Statistics in Agriculture
First Page
73
Last Page
81
DOI
10.4148/2475-7772.1176
Conference Title
15th Annual Conference on Applied Statistics in Agriculture
Conference Date
April 27-29, 2003
City
Manhattan, Kansas
Abstract
High plasma cholesterol (particularly high LDL-cholesterol) is a high risk factor for coronary heart disease (CHD), which causes a high CHD morbidity and mortality. Besides clinical drugs, more and more interest is focused on finding natural components in the diet that may have hypocholesterolemic effects. Plant sterols are natural components in human diets and found to have cholesterol-lowering effects in humans. Sheanut oil has a relatively high amolmt of plant sterols. Therefore, the two experiments were designed to investigate the hypocholesterolemic effect of sheanut oil in hamsters. The response was not monotonic. Low doses increased plasma cholesterol, but high doses decreased plasma cholesterol. Because there was partial dose repetition between the two experiments, the two were combined together to estimate the dose leading to the highest cholesterol concentration and the dose leading to the same cholesterol concentration as the control group. A quadratic model was selected to fit the combined data after appropriate transformation of exploratory and response variable. Nonparametric smoothing method was used to justify the quadratic model. The results of point estimation and confidence interval were compared by Delta, Fieller's and bootstrapping methods.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Copyright Owner
The Authors
Copyright Date
2003
Language
en
File Format
application/pdf
Recommended Citation
Zjhang, Wuyan; Nissen, Steve; Beitz, Donald; and Dixon, Philip, "Quadratic model to estimate the doses causing the highest cholesterol concentration and the same cholesterol concentration as control group" (2003). Statistics Conference Proceedings, Presentations and Posters. 16.
https://lib.dr.iastate.edu/stat_las_conf/16
Included in
Animal Sciences Commons, Applied Statistics Commons, Natural Products Chemistry and Pharmacognosy Commons, Statistical Methodology Commons, Statistical Models Commons
Comments
This proceeding is from Zhang, W., Nissen, S., Beitz, D., & Dixon, P. (2003). Quadratic model to estimate the doses causing the highest cholesterol concentration and the same cholesterol concentration as control group. 15th Annual Conference on Applied Statistics in Agriculture, Apr. 27-29, Manhattan, Kansas, Kansas State University. doi:10.4148/2475-7772.1176.