Document Type

Report

Publication Date

1-20-2020

Abstract

Confidence intervals for effective concentrations (EC's) are commonly computed in dose response curve analyse. Profile intervals offer an alternative method for computing the confidence intervals in situations where delta method based confidence intervals produce intervals with values outside of a practical range. In this document, we describe the computation of profile intervals for EC's. We then introduce an R function, profile.ECx(), for computing these intervals from a dose response model fit by the drm() function in the drc package. Supplemental material includes three files of R code that define profile.ECx() and its helper functions and R code and data for the two examples.

Comments

See the attached supplemental files below.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

ProfileCI.zip (206 kB)
Supplemental files described in abstract

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