A case-control study was conducted to assess the association of major swine viral pathogens, including porcine circovirus type 2 (PCV2) with postweaning multisystemic wasting syndrome (PMWS). Cases were defined as individual pigs with a clinical history of progressive weight loss and respiratory signs and that were subsequently diagnosed with PMWS on the basis of characteristic histopathological lesions. Controls were pigs clinically unaffected and/or from herds in which PMWS had not been diagnosed and with no clinical signs compatible with PMWS. A total of 31 cases and 56 controls were identified from diagnostic submissions or farms within a 6-month period. Among viruses examined, PCV2 appeared to be the most strongly associated with PMWS (P<.05). Risk for PWMS was much higher if animal was coinfected with porcine reproductive and respiratory syndrome virus (odd ratio =31.2). However, PCV2 was found in 62.5% of the control animals and was not detected in 2 of the 31 PMWS pigs. Furthermore, no significant genetic difference was observed among PCV2 isolates from PMWS and clinically normal pigs. The role of PCV2 in PMWS remains to be reassessed.
Iowa State University
Pogranichnyy, R.; Harms, P. A.; Sorden, S. D.; and Yoon, K.-J., "A Field-Based Assessing the Role of PCV-2 and Other Swine Viruses in Postweaning Multisystemic Wasting Syndrome" (2001). Swine Research Report, 2000. 42.