Campus Units
Veterinary Clinical Sciences
Document Type
Article
Publication Version
Published Version
Publication Date
11-1-2014
Journal or Book Title
Journal of the American Veterinary Medical Association
Volume
245
Issue
9
First Page
1015
Last Page
1020
DOI
10.2460/javma.245.9.1015
Abstract
Objective—To evaluate the effect of dosing interval on the efficacy of maropitant for prevention of opioid-induced vomiting and signs of nausea in dogs.
Design—Randomized prospective clinical study.
Animals—50 client-owned dogs that underwent an elective surgical procedure.
Procedures—Dogs were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC), then hydromorphone (0.1 mg/kg [0.045 mg/lb], IM) at 0 (simultaneously; group 0; n = 10), 15 (group 15; 10), 30 (group 30; 10), 45 (group 45; 10), or 60 (group 60; 10) minutes later. Dogs were monitored for vomiting and signs of nausea for 30 minutes after hydromorphone administration. A historical control group of similar dogs (n = 9) that were administered hydromorphone (0.1 mg/kg, IM) but not maropitant served as the referent for comparison purposes.
Results—Vomiting was recorded for 6 dogs in group 0 and 2 dogs in group 15. Signs of nausea were recorded for 10 dogs in group 0, 9 dogs in group 15, 8 dogs in group 30, 6 dogs in group 45, and 1 dog in group 60. Compared with dogs in the historical control group, vomiting was significantly decreased and prevented when maropitant was administered 15 and 30 minutes, respectively, before hydromorphone; signs of nausea were significantly decreased only when maropitant was administered 60 minutes before hydromorphone.
Conclusions and Clinical Relevance—Results indicated that vomiting was significantly decreased and then prevented when maropitant was administered to dogs 15 and 30 minutes before hydromorphone. However, signs of nausea were significantly decreased only when the dosing interval was 60 minutes.
Copyright Owner
American Veterinary Medical Association
Copyright Date
2014
Language
en
File Format
application/pdf
Recommended Citation
Hay Kraus, Bonnie L., "Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs" (2014). Veterinary Clinical Sciences Publications. 13.
https://lib.dr.iastate.edu/vcs_pubs/13
Included in
Comparative and Laboratory Animal Medicine Commons, Small or Companion Animal Medicine Commons, Veterinary Toxicology and Pharmacology Commons
Comments
This article is published as Kraus, Bonnie L. Hay. "Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs." Journal of the American Veterinary Medical Association 245, no. 9 (2014): 1015-1020. doi: 10.2460/javma.245.9.1015. Posted with permission.