Campus Units

Veterinary Clinical Sciences, Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

2018

Journal or Book Title

Journal of Veterinary Internal Medicine

Volume

32

Issue

3

First Page

1160

Last Page

1165

DOI

10.1111/jvim.15062

Abstract

Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma‐associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre‐surgical database.

Comments

This article is published as Loewen, Jennifer M., Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, and Dana N. LeVine. "Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog." Journal of veterinary internal medicine (2018). doi: 10.1111/jvim.15062.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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