Campus Units
Veterinary Clinical Sciences
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
3-2018
Journal or Book Title
The Veterinary Journal
Volume
233
First Page
63
Last Page
65
DOI
10.1016/j.tvjl.2018.01.003
Abstract
Spontaneous chronic corneal epithelial defects (SCCEDs) are characteristic ulcers in dogs that are refractory to healing. The aim of the study was to evaluate the use of a topical regenerative agent to promote healing of SCCEDs. Nineteen dogs (20 eyes) were randomized to receive either regenerative agent (10 eyes) or placebo (10 eyes) every 48 h following corneal debridement, which was repeated 1 week later if the SCCED had not yet healed. The mean ± standard deviation time to re-epithelialization was 17.3 ± 12.8 days for the group treated with a topical regenerative agent and 19.3 ± 11.7 days for the group treated with a placebo; the cumulative healing rates were not statistically different (P > 0.650). A positive association was found between the initial size of the ulcer and the time to re-epithelialization (r = 0.555, P = 0.011). Although well tolerated by dogs, there was no therapeutic advantage in using a topical regenerative agent for re-epithelialization of SCCEDs.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Copyright Owner
Elsevier Ltd.
Copyright Date
2018
Language
en
File Format
application/pdf
Recommended Citation
Sebbag, Lionel; Allbaugh, Rachel A.; Strong, Travis; Strauss, Rachel; Wehrman, Rita F.; Foote, Braidee C.; Peterson, Chimene S.; and Ben-Shlomo, Gil, "Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study" (2018). Veterinary Clinical Sciences Publications. 27.
https://lib.dr.iastate.edu/vcs_pubs/27
Included in
Ophthalmology Commons, Small or Companion Animal Medicine Commons, Veterinary Toxicology and Pharmacology Commons
Comments
This is a manuscript of an article published as Sebbag, L., R. Allbaugh, T. Strong, R. Strauss, R. Wehrman, B. Foote, C. Peterson, and G. Ben-Shlomo. "Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study." The Veterinary Journal 233 (2018): 63-65. DOI: 10.1016/j.tvjl.2018.01.003. Posted with permission.