Campus Units

Veterinary Clinical Sciences

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

3-2018

Journal or Book Title

The Veterinary Journal

Volume

233

First Page

63

Last Page

65

DOI

10.1016/j.tvjl.2018.01.003

Abstract

Spontaneous chronic corneal epithelial defects (SCCEDs) are characteristic ulcers in dogs that are refractory to healing. The aim of the study was to evaluate the use of a topical regenerative agent to promote healing of SCCEDs. Nineteen dogs (20 eyes) were randomized to receive either regenerative agent (10 eyes) or placebo (10 eyes) every 48 h following corneal debridement, which was repeated 1 week later if the SCCED had not yet healed. The mean ± standard deviation time to re-epithelialization was 17.3 ± 12.8 days for the group treated with a topical regenerative agent and 19.3 ± 11.7 days for the group treated with a placebo; the cumulative healing rates were not statistically different (P > 0.650). A positive association was found between the initial size of the ulcer and the time to re-epithelialization (r = 0.555, P = 0.011). Although well tolerated by dogs, there was no therapeutic advantage in using a topical regenerative agent for re-epithelialization of SCCEDs.

Comments

This is a manuscript of an article published as Sebbag, L., R. Allbaugh, T. Strong, R. Strauss, R. Wehrman, B. Foote, C. Peterson, and G. Ben-Shlomo. "Lack of effect of a topical regenerative agent on re-epithelialization rate of canine spontaneous chronic corneal epithelial defects: A randomized, double-masked, placebo-controlled study." The Veterinary Journal 233 (2018): 63-65. DOI: 10.1016/j.tvjl.2018.01.003. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

Elsevier Ltd.

Language

en

File Format

application/pdf

Available for download on Friday, March 01, 2019

Published Version

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