Campus Units
Biomedical Sciences, Veterinary Clinical Sciences
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
11-12-2018
Journal or Book Title
Journal of Feline Medicine and Surgery
DOI
10.1177%2F1098612X18810867
Abstract
Objectives
The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval.
Methods
The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values/min, confirmed at two or more separate visits.
Results
Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease was bilateral in 5/10 cats. Clinical signs included conjunctivitis (14/17 eyes), corneal ulceration (6/17 eyes), non-ulcerative keratitis (4/17 eyes), symblepharon (4/17 eyes), eosinophilic keratitis (3/17 eyes), corneal sequestrum (3/17 eyes), corneal fibrosis (2/17 eyes) and meibomitis (2/17 eyes). Management included topically applied lacrimomimetics, antiviral drugs, corticosteroids or immunomodulatory drugs; orally administered famciclovir; or surgical procedures, in various combinations. Response to therapy (defined as an increase in STT-1 value of ⩾5 mm/min) was transient (seen at a single reassessment) in 65% of eyes and sustained (seen at ⩾2 consecutive reassessments) in 18% of eyes.
Conclusions and relevance
Clinical features seen in cats with low STT-1 values are described, although the association between aqueous deficiency and the reported ocular changes is unknown at this time. We encourage clinicians to assess the tear film in cats with ocular surface disease, and initiate therapy with lacrimomimetics if STT-1 values are repeatedly below normal. Such information will further define aqueous tear deficiency in cats, providing a better understanding of disease prevalence, pathogenesis and treatment.
Copyright Owner
The Authors
Copyright Date
2018
Language
en
File Format
application/pdf
Recommended Citation
Uhl, Lisa K.; Saito, Akihiko; Iwashita, Hiroko; Maggs, David J.; Mochel, Jonathan P.; and Sebbag, Lionel, "Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)" (2018). Veterinary Clinical Sciences Publications. 28.
https://lib.dr.iastate.edu/vcs_pubs/28
Included in
Ophthalmology Commons, Small or Companion Animal Medicine Commons, Veterinary Preventive Medicine, Epidemiology, and Public Health Commons
Comments
This is a manuscript of an article published as Uhl, Lisa K., Akihiko Saito, Hiroko Iwashita, David J. Maggs, Jonathan P. Mochel, and Lionel Sebbag. "Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)." Journal of Feline Medicine and Surgery (2018). DOI: 10.1177%2F1098612X18810867. Posted with permission of SAGE Publications.