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Veterinary Clinical Sciences

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Veterinary Anaesthesia and Analgesia





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Objective The goal of this study was to evaluate the effectiveness of maropitant (Cerenia®) in preventing vomiting after premedication with hydromorphone.

Study design Randomized, blinded, prospective clinical study.

Animals Eighteen dogs ASA I/II admitted for elective orthopedic surgical procedures. The dogs were a mixed population of males and females, purebreds and mixed breeds, 1.0–10.2 years of age, weighing 3–49.5 kg.

Methods Dogs were admitted to the study if they were greater than 1 year of age, healthy and scheduled to undergo elective orthopedic surgery. Dogs were randomly selected to receive one of two treatments administered by subcutaneous injection. Group M received 1.0 mg kg−1 of maropitant, Group S received 0.1 mL kg−1 of saline 1 hour prior to anesthesia premedication. Dogs were premedicated with 0.1 mg kg−1 of hydromorphone intramuscularly. A blinded observer documented the presence of vomiting, retching and/or signs of nausea for 30 minutes after premedication.

Results All dogs in S vomited (6/9), retched (1/9) or displayed signs of nausea (2/9). None (0/9) of the dogs in M vomited, retched or displayed signs of nausea. Dogs in M had significantly fewer incidences of vomiting (p=0.0090), vomiting and retching (p=0.0023) and vomiting, retching and nausea (p<0.0001) when compared to S.

Conclusion and clinical relevance Maropitant prevents vomiting, retching and nausea associated with intramuscular hydromorphone administration in dogs.


This is the peer-reviewed version of the following article: Kraus, Bonnie L. Hay. "Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone." Veterinary Anaesthesia and Analgesia 40, no. 1 (2013): 28-34, which has been published in final form at DOI: 10.1111/j.1467-2995.2012.00788.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.

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Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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The Author, Veterinary Anaesthesia and Analgesia, Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia



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