Campus Units
Veterinary Clinical Sciences, Biomedical Sciences
Document Type
Article
Publication Version
Published Version
Publication Date
2-23-2019
Journal or Book Title
Journal of Veterinary Medicine and Surgery
Volume
3
Issue
1
First Page
22
Abstract
This report documents the progression of chronic lymphocytic leukemia into diffuse aggressive lymphoma, or Richter’s syndrome, first manifesting as unilateral ophthalmic disease in a 10-year-old coonhound. Following a 1.5-year course of chronic leukemia that was in a clinical remission, the dog was presented for a protruded left globe. Orbital ultrasound revealed a vascular mass located ventromedially and causing indentation of the sclera. Skull computed tomography showed exophthalmos due to a soft tissue mass and concurrent left mandibular bony lysis. Abdominal ultrasound and computed tomography revealed a large right adrenal mass, peritoneal lymphadenopathy, multiple liver nodules, kidney infarcts, and dorsal body wall nodules. A diagnosis of uveal lymphoma with scleral extension was obtained on histopathology after surgical removal of the affected eye. Cancerous cells were large with high-grade proliferative features, consistent with T-cell lymphoma based on immunophenotyping (CD3+/CD20-). The dog was euthanized 2 days postoperatively due to declining systemic condition. Richter’s syndrome is a rare condition, but generally carries a grave prognosis. To the authors’ knowledge, this is the first report of Richter’s syndrome in a veterinary patient presenting with an ophthalmic manifestation.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Owner
Wehrman RF, et al.
Copyright Date
2019
Language
en
File Format
application/pdf
Recommended Citation
Wehrman, Rita; Sebbag, Lionel; Reilly, Chris M.; Allbaugh, Rachel A.; Ben-Shlomo, Gil; Berger, Erika P.; and Musser, Margaret L., "Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report" (2019). Veterinary Clinical Sciences Publications. 42.
https://lib.dr.iastate.edu/vcs_pubs/42
Comments
This article is published as Wehrman, Rita F, Lionel Sebbag, Chris M Reilly, Rachel A Allbaugh, Gil Ben-Shlomo, Erika P Berger, and Margaret L Musser. "Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report." Journal of Veterinary Medicine and Surgery 3, no. 1 (2019): 22. Posted with permission.