Veterinary Clinical Sciences, Biomedical Sciences
Journal or Book Title
Journal of Veterinary Medicine and Surgery
This report documents the progression of chronic lymphocytic leukemia into diffuse aggressive lymphoma, or Richter’s syndrome, first manifesting as unilateral ophthalmic disease in a 10-year-old coonhound. Following a 1.5-year course of chronic leukemia that was in a clinical remission, the dog was presented for a protruded left globe. Orbital ultrasound revealed a vascular mass located ventromedially and causing indentation of the sclera. Skull computed tomography showed exophthalmos due to a soft tissue mass and concurrent left mandibular bony lysis. Abdominal ultrasound and computed tomography revealed a large right adrenal mass, peritoneal lymphadenopathy, multiple liver nodules, kidney infarcts, and dorsal body wall nodules. A diagnosis of uveal lymphoma with scleral extension was obtained on histopathology after surgical removal of the affected eye. Cancerous cells were large with high-grade proliferative features, consistent with T-cell lymphoma based on immunophenotyping (CD3+/CD20-). The dog was euthanized 2 days postoperatively due to declining systemic condition. Richter’s syndrome is a rare condition, but generally carries a grave prognosis. To the authors’ knowledge, this is the first report of Richter’s syndrome in a veterinary patient presenting with an ophthalmic manifestation.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Wehrman RF, et al.
Wehrman, Rita; Sebbag, Lionel; Reilly, Chris M.; Allbaugh, Rachel A.; Ben-Shlomo, Gil; Berger, Erika P.; and Musser, Margaret L., "Richter’s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report" (2019). Veterinary Clinical Sciences Publications. 42.