Campus Units

Veterinary Clinical Sciences, Veterinary Microbiology and Preventive Medicine, Veterinary Pathology

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

4-22-2020

Journal or Book Title

Journal of Equine Veterinary Science

First Page

103102

DOI

10.1016/j.jevs.2020.103102

Abstract

A reformulation of Mycobacterium cell wall fraction immunotherapeutic can be used to successfully treat sarcoids in horses. Sarcoids are reported to be the most common equine skin tumors with tumor type and location influencing the choice of treatment. Wide surgical excision is curative for many tumors, but may not always be feasible. Previous studies have reported sarcoid regression after injection with mycobacterial cell wall immunotherapeutics. A new formulation of the Mycobacterium phlei cell wall fraction immunostimulant (Immunocidin® Equine) was utilized to treat cutaneous tumors in horses. Equids with skin tumors diagnosed as sarcoids were enrolled in the study. Sarcoids were injected at the initial visit with Immunocidin® Equine and subsequently at approximately 2-week intervals. Of 17 cases, 9 cases were completely resolved at the end of the study period evaluation or at time of final follow up (52.9%). Three cases were reported as improved (smaller), but not resolved (17.6%). Three cases were discontinued from the study as the respective masses were growing larger or not resolving (17.6%). One case (5.8%) with two masses had resolution of one mass, whereas the other tumor had a small regrowth 5 months after the last treatment. One case (5.8%) was lost to follow up. All cases had mild to moderate swelling of the injection site, and some cases had discharge after the second, third, or fourth injections. No serious systemic side effects or complications were encountered during the study.

Comments

This is a manuscript of an article published as Caston, Stephanie S., Brett A. Sponseller, Katarzyna A. Dembek, and Jesse M. Hostetter. "Evaluation of locally injected Mycobacterium cell wall fraction in horses with sarcoids." Journal of Equine Veterinary Science (2020): 103102. DOI: 10.1016/j.jevs.2020.103102. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

Published Version

Share

COinS