Campus Units
Veterinary Clinical Sciences, Veterinary Pathology
Document Type
Article
Publication Version
Accepted Manuscript
Publication Date
3-2017
Journal or Book Title
Veterinary Ophthalmology
Volume
20
Issue
2
First Page
171
Last Page
176
DOI
10.1111/vop.12387
Abstract
Objective To determine if topical ophthalmic diclofenac sodium 0.1% solution alters renal parameters in the domestic chicken, and to determine if the drug is detectable in plasma after topical ophthalmic administration.
Animals Thirty healthy domestic chickens
Procedures Over seven days, 6 birds were treated unilaterally with 1 drop of artificial tear solution (group 1), 12 birds were treated unilaterally (group 2) and 12 bilaterally (group 3) with diclofenac sodium 0.1% ophthalmic solution. Treatments were provided for 7 days, every 12 hours in all groups. Pre- and post-treatment plasma samples from all birds were evaluated for changes in albumin, total protein, and uric acid. Post-treatment samples of all birds were also analyzed by HPLC-MS for detection of diclofenac sodium.
Results Changes in pre- and post-treatment plasma albumin were significant (P < 0.05) in groups 2 and 3, but not for group 1. Pre- and post-treatment changes in total protein and uric acid pre- and post-treatment were not significant for any group. Diclofenac sodium was not detectable (limit of detection = 0.10 ng/mL) in plasma samples from birds in group 1. Concentration of drug in group 3 was statistically greater than group 2 (P = 0.0008).
Conclusions and Clinical Relevance Topical ophthalmic diclofenac sodium 0.1% administered every 12 hours in one or both eyes for 7 days is detectable in systemic circulation in the domestic chicken at 15 minutes post-administration, but did not cause overt changes in parameters used to monitor renal physiology.
Copyright Owner
American College of Veterinary Ophthalmologists
Copyright Date
2016
Language
en
File Format
application/pdf
Recommended Citation
Griggs, Angela N.; Yaw, Taylor J.; Haynes, Joseph S.; Ben-Shlomo, Gil; Tofflemire, Kyle L.; and Allbaugh, Rachel A., "Bioavailability and biochemical effects of diclofenac sodium 0.1% ophthalmic solution in the domestic chicken (Gallus gallus domesticus)" (2017). Veterinary Clinical Sciences Publications. 8.
https://lib.dr.iastate.edu/vcs_pubs/8
Included in
Comparative and Laboratory Animal Medicine Commons, Poultry or Avian Science Commons, Veterinary Pathology and Pathobiology Commons
Comments
This is the peer reviewed version of the following article: Griggs, A. N., Yaw, T. J., Haynes, J. S., Ben-Shlomo, G., Tofflemire, K. L. and Allbaugh, R. A. (2017), Bioavailability and biochemical effects of diclofenac sodium 0.1% ophthalmic solution in the domestic chicken (Gallus gallus domesticus). Vet Ophthalmol, 20: 171–176, which has been published in final form at DOI: 10.1111/vop.12387. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.