Campus Units

Veterinary Diagnostic and Production Animal Medicine, Statistics

Document Type

Article

Publication Version

Published Version

Publication Date

12-2019

Journal or Book Title

Animal Health Research Reviews

Volume

20

Issue

2

First Page

274

Last Page

290

DOI

10.1017/S1466252319000173

Abstract

A systematic review and network meta-analysis (MA) was conducted to address the question, ‘What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?’ Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Network MA was undertaken for morbidity, mortality, and the presence or absence of non-specific lung lesions. However, there was not a sufficient body of research evaluating the same interventions and outcomes to allow a meaningful synthesis of the comparative efficacy of the vaccines. To build this body of research, additional rigor in trial design and analysis, and detailed reporting of trial methods and results are warranted.

Comments

This article is published as Sargeant, Jan M., Dapeng Hu, Annette M. O’Connor, Chong Wang et al. "Efficacy of bacterial vaccines to prevent respiratory disease in swine: a systematic review and network meta-analysis." Animal Health Research Reviews 20, no. 2 (2019): 274-290. DOI: 10.1017/S1466252319000173. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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