Campus Units
Veterinary Diagnostic and Production Animal Medicine, Veterinary Diagnostic Laboratory
Document Type
Article
Publication Version
Published Version
Publication Date
9-7-2020
Journal or Book Title
Viruses
Volume
12
Issue
9
First Page
992
DOI
10.3390/v12090992
Abstract
Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important ecologic characteristics, the infection dynamics and environmental distribution of PoAstV3 were investigated in a herd with PoAstV3-associated neurologic disease. Over a 22 week period, the frequency of PoAstV3 fecal shedding varied by pig and age. The peak detection by RT-qPCR of PoAstV3 on fecal swabs (95%; 61 of 64) occurred at 3 weeks of age. The lowest frequency of detection was at 21 weeks of age (4%; 2 of 47); however, the frequency increased to 41% (19 of 46) at the final sampling time point (25 weeks of age). Viremia was rare (0.9%: 4 of 433). Detection in oral fluid was consistent with 75% to 100% of samples positive at each time point. Pens and feeders also had a high rate of detection with a majority of samples positive at a majority of sampling time points. Based on the data presented, PoAstV3 can be consistently detected in the environment with a majority of pigs being infected and a subset intermittently shedding the virus in feces out to 25 weeks of age. These findings suggest the importance of as-yet unidentified risk factors associated with the development of PoAstV3-associated polioencephalomyelitis.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright Owner
The Author(s)
Copyright Date
2020
Language
en
File Format
application/pdf
Recommended Citation
Rawal, Gaurav; Matias Ferreyra, Franco S.; Macedo, Nubia R.; Bradner, Laura K.; Harmon, Karen M.; Allison, Grant; Linhares, Daniel C.L.; and Wilberts, Bailey L., "Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease" (2020). Veterinary Diagnostic and Production Animal Medicine Publications. 198.
https://lib.dr.iastate.edu/vdpam_pubs/198
Included in
Large or Food Animal and Equine Medicine Commons, Veterinary Infectious Diseases Commons
Comments
This article is published as Rawal, Gaurav, Franco Matias Ferreyra, Nubia R. Macedo, Laura K. Bradner, Karen M. Harmon, Grant Allison, Daniel CL Linhares, and Bailey L. Arruda. "Ecology of Porcine Astrovirus Type 3 in a Herd with Associated Neurologic Disease." Viruses 12, no. 9 (2020): 992. DOI: 10.3390/v12090992. Posted with permission.