Campus Units
Veterinary Diagnostic and Production Animal Medicine, Biomedical Sciences, Statistics
Document Type
Article
Publication Version
Published Version
Publication Date
2011
Journal or Book Title
Journal of Veterinary Internal Medicine
Volume
25
Issue
4
First Page
934
Last Page
943
DOI
10.1111/j.1939-1676.2011.0749.x
Abstract
Background: Ketamine has immunomodulating effects both in vitro and in vivo during experimental endotoxemia in humans, rodents, and dogs.
Hypothesis: Subanesthetic doses of ketamine will attenuate the clinical and immunologic responses to experimental endotoxemia in horses.
Animals: Nineteen healthy mares of various breeds.
Methods: Experimental study. Horses were randomized into 2 groups: ketamine-treated horses (KET; n = 9) and saline-treated horses (SAL; n = 10). Both groups received 30 ng/kg of lipopolysaccharide (LPS, Escherichia coli, O55:B5) 1 hour after the start of a continuous rate infusion (CRI) of racemic ketamine (KET) or physiologic saline (SAL). Clinical and hematological responses were documented and plasma concentrations of tumor necrosis factor-α (TNF-α) and thromboxane B2 (TXB2) were quantified.
Results: All horses safely completed the study. The KET group exhibited transient excitation during the ketamine loading infusion (P < .05) and 1 hour after discontinuation of administration (P < .05). Neutrophilic leukocytosis was greater in the KET group 8 and 24 hours after administration of LPS (P < .05). Minor perturbations of plasma biochemistry results were considered clinically insignificant. Plasma TNF-α and TXB2 production peaked 1.5 and 1 hours, respectively, after administration of LPS in both groups, but a significant difference between treatment groups was not demonstrated.
Conclusions and Clinical Importance: A subanesthetic ketamine CRI is well tolerated by horses. A significant effect on the clinical or immunologic response to LPS administration, as assessed by clinical observation, hematological parameters, and TNF-α and TXB2production, was not identified in healthy horses with the subanesthetic dose of racemic ketamine utilized in this study.
Rights
Journal of Veterinary Internal Medicine articles are published under the terms of the Creative Commons Attribution Non-Commercial License (CC BY NC), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Copyright Owner
American College of Veterinary Internal Medicine
Copyright Date
2011
Language
en
File Format
application/pdf
Recommended Citation
Alcott, Cody J.; Sponseller, Brett A.; Wong, David M.; Davis, J. L.; Soliman, A. M.; Wang, Chong; and Hsu, Walter H., "Clinical and Immunomodulating Effects of Ketamine in Horses with Experimental Endotoxemia" (2011). Veterinary Diagnostic and Production Animal Medicine Publications. 47.
https://lib.dr.iastate.edu/vdpam_pubs/47
Included in
Large or Food Animal and Equine Medicine Commons, Statistical Methodology Commons, Veterinary Microbiology and Immunobiology Commons, Veterinary Toxicology and Pharmacology Commons
Comments
This article is from Journal of Veterinary Internal Medicine 25 (2011); 934: doi: 10.1111/j.1939-1676.2011.0749.x. Posted with permission.