Campus Units

Veterinary Microbiology and Preventive Medicine, Veterinary Diagnostic and Production Animal Medicine

Document Type

Article

Publication Version

Published Version

Publication Date

2016

Journal or Book Title

Infectious Diseases and Translational Medicine

Volume

2

Issue

3

First Page

109

Last Page

119

DOI

10.11979/idtm.201603005

Abstract

Campylobacter jejuni has long been recognized as a main food-borne pathogen in many parts of the world. Natural reservoirs include a wide variety of domestic and wild birds and mammals, whose intestines offer a suitable biological niche for the survival and dissemination of the organism. Understanding the genetic basis of the biology and pathogenicity of C. jejuni is vital to prevent and control Campylobacter-associated infections. The recent progress in sequencing techniques has allowed for a rapid increase in our knowledge of the molecular biology and the genetic structures of Campylobacter. Single-molecule realtime (SMRT) sequencing, which goes beyond four-base sequencing, revealed the role of DNA methylation in modulating the biology and virulence of C. jejuni at the level of epigenetics. In this review, we will provide an up-to-date review on recent advances in understanding C. jejuni genomics, including structural features of genomes, genetic traits of virulence, population genetics, and epigenetics.

Comments

This article is published as Wu, Zuowei, Kathy Mou, Orhan Sahin, and Qijing Zhang. "Genomic Insights into Campylobacter jejuni Virulence and Population Genetics." Infectious Diseases and Translational Medicine 2, no. 3 (2016): 109-119. doi: 10.11979/idtm.201603005. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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