Veterinary Microbiology and Preventive Medicine, Veterinary Diagnostic and Production Animal Medicine
Journal or Book Title
Infectious Diseases and Translational Medicine
Campylobacter jejuni has long been recognized as a main food-borne pathogen in many parts of the world. Natural reservoirs include a wide variety of domestic and wild birds and mammals, whose intestines offer a suitable biological niche for the survival and dissemination of the organism. Understanding the genetic basis of the biology and pathogenicity of C. jejuni is vital to prevent and control Campylobacter-associated infections. The recent progress in sequencing techniques has allowed for a rapid increase in our knowledge of the molecular biology and the genetic structures of Campylobacter. Single-molecule realtime (SMRT) sequencing, which goes beyond four-base sequencing, revealed the role of DNA methylation in modulating the biology and virulence of C. jejuni at the level of epigenetics. In this review, we will provide an up-to-date review on recent advances in understanding C. jejuni genomics, including structural features of genomes, genetic traits of virulence, population genetics, and epigenetics.
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Wu, Zuowei; Mou, Kathy; Sahin, Orhan; and Zhang, Qijing, "Genomic Insights into Campylobacter jejuni Virulence and Population Genetics" (2016). Veterinary Microbiology and Preventive Medicine Publications. 139.