Veterinary Microbiology and Preventive Medicine
Journal or Book Title
Antimicrobial Agents and Chemotherapy
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.
American Society for Microbiology
Mu, Yang; Shen, Zhangqi; Jeon, Byeonghwa; Dai, Lei; and Zhang, Qijing, "Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics" (2013). Veterinary Microbiology and Preventive Medicine Publications. 157.