Campus Units
Veterinary Microbiology and Preventive Medicine
Document Type
Article
Publication Version
Published Version
Publication Date
9-2013
Journal or Book Title
Antimicrobial Agents and Chemotherapy
Volume
57
Issue
9
First Page
4575
Last Page
4577
DOI
10.1128/AAC.00605-13
Abstract
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.
Copyright Owner
American Society for Microbiology
Copyright Date
2013
Language
en
File Format
application/pdf
Recommended Citation
Mu, Yang; Shen, Zhangqi; Jeon, Byeonghwa; Dai, Lei; and Zhang, Qijing, "Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics" (2013). Veterinary Microbiology and Preventive Medicine Publications. 157.
https://lib.dr.iastate.edu/vmpm_pubs/157
Included in
Molecular Genetics Commons, Veterinary Microbiology and Immunobiology Commons, Veterinary Preventive Medicine, Epidemiology, and Public Health Commons
Comments
This article is published as Mu, Yang, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, and Qijing Zhang. "Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics." Antimicrobial agents and chemotherapy 57, no. 9 (2013): 4575-4577. doi: 10.1128/AAC.00605-13. Posted with permission.