Campus Units

Veterinary Microbiology and Preventive Medicine

Document Type

Article

Publication Version

Published Version

Publication Date

2-1988

Journal or Book Title

American Journal of Veterinary Research

Volume

49

Issue

2

First Page

160

Last Page

163

Abstract

Nonopsonized Brucella abortus and bacteria treated with fresh antiserum, heat-inactivated antiserum, or normal bovine serum were evaluated for their ability to stimulate production of superoxide anion and myeloperoxidasemediated iodination by neutrophils from cattle. Brucella abortus opsonized with fresh antiserum or beat-inactivated antiserum stimulated production of approximately 3 nmol of 0 2 -/106 neutrophils/30 min. Similarly treated bacteria also stimulated the binding of approximately 4.3 nmol of Nal/107 neutrophils/h to protein. Significant CP < 0.05) production of 0 2 - and iodination activity by neutrophils were not stimulated by nonopsonized bacteria or organisms treated with normal bovine serum. Seemingly, B abortus stimulated oxidative metabolism in bovine neutrophils; however, the stimulation was dependent on the presence of bacterial usociated opsonins.

Comments

This article is published as Canning, P.C., B.K. Deyoe, and J.A. Roth. 1988. Opsonin-dependent stimulation of bovine neutrophil oxidative metabolism by Brucella abortus. Am J Vet Res, 49:160-163.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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