Campus Units

Veterinary Microbiology and Preventive Medicine

Document Type

Article

Publication Version

Published Version

Publication Date

7-1993

Journal or Book Title

Journal of Virology

Volume

67

Issue

7

First Page

4399

Last Page

4403

Abstract

Transient expression assays using the reporter gene that encodes chloramphenicol acetyltransferase were used to identify cis-acting sequences necessary for bovine immunodeficiency-like virus (BIV) transactivation. Computer analyses identified two RNA stem-loop structures located immediately downstream of the transcription start site in the long terminal repeat. Deletion analysis of the long terminal repeat indicated that sequences containing the proximal stem-loop structure located between +4 and +31 are required for virus-specific transactivation. Therefore, BIV likely utilizes a mechanism of transactivation similar to that of the human and simian lentiviruses.

Comments

This article is published as Carpenter, S., S. A. Nadin-Davis, Y. Wannemuehler, and J. A. Roth. "Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus." Journal of virology 67, no. 7 (1993): 4399-4403. Posted with permission.

Copyright Owner

American Society for Microbiology

Language

en

File Format

application/pdf

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