Campus Units

Veterinary Microbiology and Preventive Medicine

Document Type

Article

Publication Version

Published Version

Publication Date

4-15-1995

Journal or Book Title

Journal of the American Veterinary Medical Association

Volume

206

Issue

8

First Page

1208

Last Page

1216

Abstract

Immunologic evaluation of vaccines has depended largely on the measurement of an antibody response in the serum of recipient animals. This approach, which worked well for diseases prevented in large part by humoral immunity, ignored the contributions cell-mediated immunity (CMI) or mucosal immunity make to providing protection against many infectious diseases. As a result of this approach, certain vaccines were marketed that produced a satisfactory antibody response but failed to protect vaccinates in the field from disease. In the modem biologics industry, there is increasing pressure for vaccine improvements and new technologic advancements to be based on a sound understanding of the entire basis for immunity, including cell-mediated, mucosal, and humoral immunity that develops after exposure to infectious disease agents.

Comments

This article is published as Coe-Clough, N.E. and J.A. Roth. 1995. Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines. J Am Vet Med Assoc, 206:1208-1216.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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