Campus Units

Veterinary Diagnostic and Production Animal Medicine, Veterinary Microbiology and Preventive Medicine, Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

11-6-2020

Journal or Book Title

Vaccines

Volume

8

Issue

4

First Page

662

DOI

10.3390/vaccines8040662

Abstract

Campylobacter jejuni clone SA has emerged as the predominant cause of ovine abortion outbreaks in the United States (US). Despite the fact that commercial Campylobacter vaccines are available, their efficacy in protecting abortion induced by C. jejuni clone SA is uncertain, and a protective vaccine is needed to control the disease. In this study, an experimental homologous bacterin (made of a clone SA isolate) and two commercial Campylobacter vaccines were evaluated for their protection against C. jejuni clone SA-induced sheep abortion. All vaccines induced high levels of antibodies against C. jejuni clone SA in pregnant ewes, but only the experimental homologous bacterin produced significant protection (80%). Immunoblotting showed that the experimental vaccine elicited more specific antibodies against C. jejuni clone SA. These findings strongly suggest the necessity of developing a homologous vaccine for the control C. jejuni clone SA induced abortion on sheep farms

Comments

This article is published as Wu, Zuowei, Michael J. Yaeger, Orhan Sahin, Changyun Xu, Ashenafi F. Beyi, Paul J. Plummer, Melda Meral Ocal, and Qijing Zhang. "A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone." Vaccines 8, no. 4 (2020): 662. DOI: 10.3390/vaccines8040662. Posted with permission.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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