Campus Units
Veterinary Diagnostic and Production Animal Medicine, Veterinary Microbiology and Preventive Medicine, Veterinary Pathology
Document Type
Article
Publication Version
Published Version
Publication Date
11-6-2020
Journal or Book Title
Vaccines
Volume
8
Issue
4
First Page
662
DOI
10.3390/vaccines8040662
Abstract
Campylobacter jejuni clone SA has emerged as the predominant cause of ovine abortion outbreaks in the United States (US). Despite the fact that commercial Campylobacter vaccines are available, their efficacy in protecting abortion induced by C. jejuni clone SA is uncertain, and a protective vaccine is needed to control the disease. In this study, an experimental homologous bacterin (made of a clone SA isolate) and two commercial Campylobacter vaccines were evaluated for their protection against C. jejuni clone SA-induced sheep abortion. All vaccines induced high levels of antibodies against C. jejuni clone SA in pregnant ewes, but only the experimental homologous bacterin produced significant protection (80%). Immunoblotting showed that the experimental vaccine elicited more specific antibodies against C. jejuni clone SA. These findings strongly suggest the necessity of developing a homologous vaccine for the control C. jejuni clone SA induced abortion on sheep farms
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright Owner
The Author(s)
Copyright Date
2020
Language
en
File Format
application/pdf
Recommended Citation
Wu, Zuowei; Yaeger, Michael J.; Sahin, Orhan; Xu, Changyun; Beyi, Ashenafi F.; Plummer, Paul J.; Ocal, Melda Meral; and Zhang, Qijing, "A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone" (2020). Veterinary Microbiology and Preventive Medicine Publications. 215.
https://lib.dr.iastate.edu/vmpm_pubs/215
Included in
Large or Food Animal and Equine Medicine Commons, Veterinary Microbiology and Immunobiology Commons, Veterinary Pathology and Pathobiology Commons, Veterinary Preventive Medicine, Epidemiology, and Public Health Commons
Comments
This article is published as Wu, Zuowei, Michael J. Yaeger, Orhan Sahin, Changyun Xu, Ashenafi F. Beyi, Paul J. Plummer, Melda Meral Ocal, and Qijing Zhang. "A Homologous Bacterin Protects Sheep against Abortion Induced by a Hypervirulent Campylobacter jejuni Clone." Vaccines 8, no. 4 (2020): 662. DOI: 10.3390/vaccines8040662. Posted with permission.