Document Type

Article

Publication Version

Published Version

Publication Date

4-1986

Journal or Book Title

Infection and Immunity

Volume

52

Issue

1

First Page

285

Last Page

292

Abstract

A low-molecular-weight Brucella abortus extract (a nucleotidelike material) inhibited zymosan-elicited neutrophil degranulation and trichloroacetic acid-precipitable protein iodination (a measure of myeloperoxidase and 8 20 2 release from neutrophilic leukocytes). Inhibition of neutrophU function was directly related to the concentration of the Brucella extract. The extract preferentially inhibited degranulation of primary (azurophUic or peroxidase positive) granules and had limited inhibition of secondary (specific or peroxidase negative) granule release but did not inhibit opsonized zymosan ingestion. Inhibition of protein iodination closely paralleled that of primary granule release but was unrelated to inhibition of secondary granule release. These results suggest that B. abortus has a component which is capable of inhibiting release of myeloperoxidase by dose-dependent preferential inhibition of primary granule release from bovine neutrophilic leukocytes.

Comments

This article is from Infection and Immunity 52 (1986): 285.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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