Campus Units

Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

11-7-2018

Journal or Book Title

The American Journal of Tropical Medicine and Hygiene

Volume

99

Issue

5

First Page

1201

Last Page

1205

DOI

10.4269/ajtmh.18-0533

Abstract

Dipylidium caninum is a cosmopolitan cestode infecting dogs, cats, and humans. Praziquantel is a highly effective cestocidal drug and resistance in adult cestodes has not been reported. From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of D. caninum were clinically resistant to praziquantel and could not be resolved despite increasing the dose, frequency, and duration of treatment. Resistant isolates were identified and characterized by sequencing the 28S, 12S, and voltage-gated calcium channel beta subunit genes. Cases were only resolved following treatment with nitroscanate or a compounded pyrantel/praziquantel/oxantel product. Clinicians should be aware of this alarming development as treatment options for cestodes are limited in both human and veterinary medicine.

Comments

This article is published as Chelladurai, Jeba Jesudoss, Tsegabirhan Kifleyohannes, Janelle Scott, and Matthew T. Brewer. "Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum." The American Journal of Tropical Medicine and Hygiene 99, no. 5 (2018): 1201-1205. DOI: 10.4269/ajtmh.18-0533. Posted with permission.

Copyright Owner

The American Society of Tropical Medicine and Hygiene

Language

en

File Format

application/pdf

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