Campus Units

Veterinary Pathology

Document Type

Article

Publication Version

Published Version

Publication Date

8-2020

Journal or Book Title

International Journal for Parasitology: Drugs and Drug Resistance

Volume

13

First Page

89

Last Page

93

DOI

10.1016/j.ijpddr.2020.06.003

Abstract

The protozoan parasite Tritrichomonas foetus causes early embryonic death in cattle which results in severe economic loss. In the United States, there are no drugs are approved for treatment of this pathogen. In this study, we evaluated in vitro anti-protozoal effects of compounds from an open access chemical library against T. foetus trophozoites. An initial high-throughput screen identified 16 compounds of interest. Further investigation revealed 12 compounds that inhibited parasite growth and 4 compounds with lethal effects. For lethal compounds, dose-response curves were constructed and the LD50 was calculated for laboratory and field strains of T. foetus. Our experiments revealed chemical scaffolds that were parasiticidal in the micromolar range, and these scaffolds provide a starting point for drug discovery efforts. Further investigation is still needed to investigate suitability of these scaffolds and related compounds in food animals. Importantly, open access chemical libraries can be useful for identifying compounds with activity against protozoan pathogens of veterinary importance.

Comments

This article is published as Martin, Katy A., Jeba R.J. Jesudoss Chelladurai, Christopher Bader, Elizabeth Carreiro, Katelyn Long, Kylie Thompson, and Matthew T. Brewer. "Repurposing the open access malaria box reveals compounds with activity against Tritrichomonas foetus trophozoites." International Journal for Parasitology: Drugs and Drug Resistance 13 (2020): 89-93. DOI: 10.1016/j.ijpddr.2020.06.003. Posted with permission.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Copyright Owner

The Author(s)

Language

en

File Format

application/pdf

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