Document Type

Article

Publication Date

1-17-2007

Journal or Book Title

Veterinary Microbiology

Volume

119

Issue

1

First Page

76

Last Page

81

DOI

10.1016/j.vetmic.2006.08.005

Abstract

The antimicrobial activity of linear, cationic α-helical peptides from cattle (BMAP28), sheep (SMAP28 and SMAP29), and pigs (PMAP23) were assessed to determine if activity was selective for Pasteurella multocida from a particular animal species or broad-spectrum against all P. multocida tested. The antimicrobial activities of synthetic peptides were determined for P. multocida isolated from cattle (10 isolates), sheep (10 isolates), and pigs (10 isolates) in a broth microdilution assay. All thirty isolates of P. multocida were susceptible to BMAP28 (MICs and MBCs, 1.0–1.9 μM); SMAP28 and SMAP29 (MICs and MBCs, 0.2–0.7 μM); and PMAP23 (MICs and MBCs, 4.3 to ≥6.8 μM). Overall, the results of this study suggest that synthesized cathelicidins from cattle, sheep, and pigs had broad-spectrum antimicrobial activity against all P. multocida.

Comments

This article is from Veterinary Microbiology 119, no. 1 (January 2007): 76–81, doi:10.1016/j.vetmic.2006.08.005.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

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