Document Type

Article

Publication Date

1-2001

Journal or Book Title

Antimicrobial Agents and Chemotherapy

Volume

45

Issue

1

First Page

331

Last Page

334

DOI

10.1128/​AAC.45.1.331-334.2001

Abstract

Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP1831, CAP1828, CAP1822, and CAP1821a were the most active, with MICs as low as 0.6 μg/ml. Other cathelicidins were less active. In lambs with pneumonia, 0.5 mg of SMAP29 reduced the concentration of bacteria in both bronchoalveolar lavage fluid and consolidated pulmonary tissues. Hence, the antimicrobial activity of SMAP29 suggests that it has applications in the treatment of respiratory tract infections.

Comments

This article is from Antimicrobial Agents and Chemotherapy 45, no. 1 (January 2001): 331–334, doi:10.1128/AAC.45.1.331-334.2001.

Copyright Owner

American Society for Microbiology

Language

en

File Format

application/pdf

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