Document Type
Article
Publication Date
9-2006
Journal or Book Title
Veterinary Pathology
Volume
43
Issue
5
First Page
595
Last Page
612
DOI
10.1354/vp.43-5-595
Abstract
The respiratory epithelium is a primary site for the deposition of microorganisms that are acquired during inspiration. The innate immune system of the respiratory tract eliminates many of these potentially harmful agents preventing their colonization. Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by respiratory epithelia, which have integral roles in host defense and inflammation in the lung. Synthesis and secretion of these molecules are regulated by the developmental stage, hormones, as well as many growth and immunoregulatory factors. The purpose of this review is to discuss antimicrobial innate immune elements within the respiratory tract of healthy and pneumonic lung with emphasis on hydrophilic surfactant proteins and β-defensins.
Copyright Owner
American College of Veterinary Pathologists
Copyright Date
2006
Language
en
File Format
application/pdf
Recommended Citation
Grubor, Branka; Meyerholz, David K.; and Ackermann, Mark R., "Collectins and cationic antimicrobial peptides of the respiratory epithelia" (2006). Veterinary Pathology Publications and Papers. 32.
https://lib.dr.iastate.edu/vpath_pubs/32
Comments
The final, definitive version of this paper has been published in Veterinary Pathology, 43/5, 9/2006 by SAGE Publications, Inc., All rights reserved. © 2006 American College of Veterinary Pathologists.