Document Type

Article

Publication Date

6-2001

Journal or Book Title

International Journal of Antimicrobial Agents

Volume

17

Issue

6

First Page

505

Last Page

510

DOI

10.1016/S0924-8579(01)00319-3

Abstract

In this study, the efficacy of ovine antimicrobial anionic peptide (AP) was assessed in a lamb model of acute pneumonia. A single intratracheal dose of the peptide, H-DDDDDDD-OH (0.5 mg) reduced pulmonary inflammation and the concentration of Mannheimia (Pasteurella) haemolytica in infected lung tissue. Administration of H-DDDDDDD-OH after infection was more effective in reducing the consolidation and lesion scores at the deposition site than its administration prior to infection. Hence, the in vivo effectiveness of AP suggests that it may have applications in the treatment of pulmonary infections. Further studies are needed to confirm these findings and also to determine the optimal doses and intervals of H-DDDDDDD-OH therapy.

Comments

This article is from International Journal of Antimicrobial Agents 17, no. 5 (June 2001): 505–510, doi:10.1016/S0924-8579(01)00319-3.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

Share

COinS