Document Type
Article
Publication Date
9-2013
Journal or Book Title
Veterinary Pathology
Volume
50
Issue
5
First Page
827
Last Page
841
DOI
10.1177/0300985813480216
Abstract
The response of the preterm and newborn lung to airborne pathogens, particles, and other insults is initially dependent on innate immune responses since adaptive responses may not fully mature and require weeks for sufficient responses to antigenic stimuli. Foreign material and microbial agents trigger soluble, cell surface, and cytoplasmic receptors that activate signaling cascades that invoke release of surfactant proteins, defensins, interferons, lactoferrin, oxidative products, and other innate immune substances that have antimicrobial activity, which can also influence adaptive responses. For viral infections such as respiratory syncytial virus (RSV), the pulmonary innate immune responses has an essential role in defense as there are no fully effective vaccines or therapies for RSV infections of humans and reinfections are common. Understanding the innate immune response by the preterm and newborn lung may lead to preventive strategies and more effective therapeutic regimens.
Copyright Owner
The author(s)
Copyright Date
2013
Language
en
File Format
application/pdf
Recommended Citation
Derscheid, Rachel J. and Ackermann, Mark R., "The Innate Immune System of the Perinatal Lung and Responses to Respiratory Syncytial Virus Infection" (2013). Veterinary Pathology Publications and Papers. 57.
https://lib.dr.iastate.edu/vpath_pubs/57
Comments
This is an author's accepted manuscript of an article from Veterinary Pathology 50 (2013): 827–841, doi:10.1177/0300985813480216. Posted with permission.