Journal or Book Title
In three separate experiments, 2- or 5-day-old commercial turkey poults were inoculated orally with astrovirus and examined for clinical signs and for gross and microscopic lesions over a period of 14 days. By day 2 postinoculation (PI), inoculated poults had de- veloped diarrhea, generalized loss of intestinal tone, and dilated ceca that contained light- yellow fluid feces and gas; these changes persisted through day 10 PI. Mild crypt hyperplasia was the only change discernible by light microscopy, and it was first noted in the proximal jejunum on day 1 PI, in the distal jejunum and ileum on day 3 PI, and in the duodenum on day 5 PI. A significant (P < 0.05) increase in crypt depth and area was documented by image analysis on day 3 PI. Ultrastructural evaluation revealed intracytoplasmic aggregates of astro- virus in enterocytes on the sides and base of villi in the ileum and distal jejunum on day 3 PI. Based on the findings, it was concluded that astrovirus caused lesions and replicated in both upper and lower segments of the small intestine in turkey poults.
American Association of Avian Pathologists
Thouvenelle, Mari L.; Haynes, Joseph S.; and Reynolds, Don L., "Astrovirus Infection in Hatchling Turkeys: Histologic, Morphometric, and Ultrastructural Findings" (1995). Veterinary Pathology Publications and Papers. 88.