Journal or Book Title
Nucleic Acids Research
The atomic force microscope (AFM;1) can image DNA and RNA in air and under solutions at resolution comparable to that obtained by electron microscopy (EM) (2–7). We have developed a method for depositing and imaging linear DNA molecules to which 5nm gold spheres have been attached. The gold spheres facilitate orientation of the DNA molecules on the mica surface to which they are adsorbed and are potentially useful as internal height standards and as high resolution gene or sequence specific tags. We show that by modulating their adhesion to the mica surface, the gold spheres can be moved with some degree of control with the scanning tip.
Oxford University Press
Shaiu, Wen-Ling; Larson, Drena D.; Vesenka, James; and Henderson, Eric, "Atomic force microscopy of oriented linear DNA molecules labeled with 5nm gold spheres" (1993). Zoology and Genetics Publications. 11.