Campus Units

Zoology

Document Type

Article

Publication Version

Published Version

Publication Date

5-29-2000

Journal or Book Title

The Journal of Cell Biology

Volume

149

Issue

5

First Page

1005

Last Page

1010

DOI

10.1083/jcb.149.5.1005

Abstract

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

Comments

This article is published as Jin, Ye, Yanming Wang, Jørgen Johansen, and Kristen M. Johansen. "JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex." The Journal of cell biology 149, no. 5 (2000): 1005-1010. doi: 10.1083/jcb.149.5.1005. Posted with permission.

Copyright Owner

The Rockefeller University Press

Language

en

File Format

application/pdf

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